Markers of oxidative stress in adults with overweight and obesity, Venezuela

Abstract

Biochemical indicators of the oxidative state could contribute in the evaluation of the risk of diseases related to oxidative imbalance. In this work, biomarkers of oxidative stress in overweight and obese adults were evaluated. 74 men and women, aged between 18-50 years, were evaluated through body mass index (BMI) and waist circumference (WC); We determined the count of leukocyte (CL), glucose (GLU), total cholesterol (TC), high density lipoprotein (HDL), low density (LDL), and very low density (VLDL),triglycerides (TG) and uric acid (UA), total bilirubin (TB), direct (DB) and indirect (IB), albumin and thiol groups as markers of oxidative stress. 20.27% presented obesity grade I (OB) and 39.18% overweight (OW) according to BMI. 49.59% of the individuals presented visceral obesity (OA). The biochemical parameters and markers of oxidative stress were within the reference ranges. People with OW and OB showed the highest values of GLU, COL, VLDL, TG and AU and DB and equally people with VO showed the statistically highest values of COL, VLDL, TG, AU, BD and CL. A positive correlation was found between the UA and the WC; between CL and WC and between CL and UA concentration. It is demonstrated that in obese people, with lipid profile and glycemia in the reference ranges, the UA and DB can be considered as the main molecules in the line of antioxidant defense.